Evolutionary-scale prediction of atomic-level protein structure with a language model

Evolutionary-scale prediction of atomic-level protein structure with a language model Recent advances in machine learning have leveraged evolutionary information in multiple sequence alignments to predict protein structure. We demonstrate direct inference of full atomic-level protein structure from primary sequence using a large language model. As language models of protein sequences are scaled up to 15 billion parameters, an atomic-resolution picture of protein structure emerges in the learned...